Current practices in prevention, screening, and treatment of diabetes in kidney transplant recipients: European survey highlights from the ERA DESCARTES Working Group
Year: 2024
Type: article
Study design: Observational Study
Abstract: Background: Although post-transplant diabetes mellitus (PTDM) is a common complication after kidney transplantation, there are few data on prevention, optimal screening, and treatment strategies. Methods: The European Renal Association's DESCARTES working group distributed a web-based survey to European transplant centres to gather information on risk assessment, screening procedures, and management practices for preventing and treating PTDM in kidney transplant recipients. Results: Answers were obtained from 121/241 transplant centres (50%) across 15 European countries. Screening practices for diabetes mellitus during the transplant work-up varied, with only 13% of centres using the recommended oral glucose tolerance test (OGTT) and 14% not screening at all. At transplantation, 19% of centres tailored the immunosuppressive regimen based on perceived PTDM risk, using strategies such as cyclosporin use or early steroid withdrawal. Fifty-two percent adopted strict glycaemic control with basal insulin in the first days post-transplant. Sixty-eight percent had defined screening protocols for early PTDM (45 days-6 months), primarily based on fasting glycaemia and/or HbA1c, while only a minority (7%) incorporated an OGTT. Changes in immunosuppression were considered by 41% in cases of early hyperglycaemia (<45 days) and by 58% in established PTDM (>45 days). Besides insulin therapy, dipeptidyl peptidase-4 (DPP4) inhibitors and metformin were most frequently used to manage early hyperglycaemia (<45 days) and PTDM (>45 days). The use of SGLT2 inhibitors and GLP-analogues increased >45 days post-transplantation. Conclusion: This European survey underscores the significant variation in PTDM prevention, screening, and treatment practices, emphasizing the imperative for more explicit guidance in approaching this complication.
Source: Clinical Kidney Journal
DOI: 10.1093/ckj/sfae367
Authors: Yassine Laghrib, Luuk Hilbrands, Gabriel C Oniscu, Marta Crespo, Ilaria Gandolfini, Christophe Mariat, Geir Mjøen, Mehmet Sukru Sever, Bruno Watschinger, Arzu Velioglu, Erol Demir, Eva Gavela Martinez, Annelies De Weerd, Ivana Dedinska, Maria Pippias, Annick Massart, Daniel Abramowicz, Johan Willem de Fijter, Christophe De Block, Rachel Hellemans
Institutions: University of Antwerp, Antwerp University Hospital, Radboud University Nijmegen, Radboud University Medical Center, Karolinska Institutet, Hospital Del Mar, University of Parma, Centre Hospitalier Universitaire de Saint-Étienne, Lovisenberg Diakonale Sykehus, Istanbul University, Medical University of Vienna, Marmara University, Koç University, Hospital Universitario Doctor Peset, Erasmus MC, Erasmus MC Transplant Institute, Martin University Hospital, North Bristol NHS Trust, University of Bristol
Language: English
Subfield: Transplantation
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,322
OpenAlex ID: W4406735361