Year: 2020
Type: article
Study design: Observational Study
Abstract: IntroductionLewy body dementia (LBD) is the second most common neurodegenerative disorder after Alzheimer’s disease (AD). In this study, we compared functional decline between LBD and AD patients, taking into account motor dysfunction, over an 18-month follow-up period.Patients and methodsWe included all patients >70 years of age, with a baseline MMSE score of ≥ 20 and a diagnosis of possible or probable LBD or AD, who attended the memory center of the Pitié-Salpêtrière hospital. Statistical analyses were performed using univariate tests and multivariate linear regression.ResultsA total of 37 AD and 36 LBD patients were included, with a median age of 81 and a median MMSE score of 24/30. Overall ADL Katz score decreased significantly for LBD people, compared to AD patients: –0.40 ± 0.75 versus 0 ± 0.24; p = 0.003. Overall IADL score decreased in the two populations but without a significant difference between the two groups: –1.71 ± 2.19 in LBD versus –1.32 (± 1.55); p = 0.38.ConclusionThis study shows a significant decrease in autonomy in LBD patients over time. LBD patients also experienced a faster decrease in autonomy than AD patients, particularly in relation to bathing, dressing, and personal care.
Source: Théâtre/Public
Author: Frank Weigand
Language: French
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4406797946