Work

Wcn25-2942 Glomerulosclerosis Is Influenced by the Mapk Signaling Pathway and the Egr1 Transcription Factor

Year: 2025

Type: article

Abstract: The global prevalence of kidney patients exceeds 850 million, with Chronic Kidney Disease (CKD) reaching 9.5% of the world's population by 2024 which is particularly notable in Central and Eastern Europe. Focal and segmental glomerulosclerosis (FSGS) is one of the main factors contributing to the progression of end-stage renal disease. Studies on markers are essential to identify causes and to develop therapeutic targets. The MAPK family proteins are related with the progression of FSGS, however, the development of this cell signaling cascade is still uncertain.

Source: Kidney International Reports

DOI: 10.1016/j.ekir.2024.11.830

Authors: Heitor Braz, Maria de Souza

Institution: Universidade de São Paulo

Language: English

Topic: Renal Diseases and Glomerulopathies

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,800