Work

Wcn25-2130 a Study to Correlate Serum Phosphorus With Marker of Endothelial Cell Dysfunction in Chronic Kidney Disease Patients on Maintenance Haemodialysis

Year: 2025

Type: article

Abstract: Methods: This is a hospital based prospective cross-sectional study which was carried out in chronic kidney disease patients in stage (3-5ND) who attended Nephrology Department, IPGMER & SSKM hospital for a period of one year, from July 2023 to July 2024.206 no.patients, randomly assigned in this study.Exclusion criteria as per study "Patients on renal replacement therapy, post renal transplant, patients on anti-resorptive drugs (bisphosphonates), contraceptives, pregnant women".Osteoporosis and osteopenia were confirmed by DEXA BMD (Dual energy X-ray absorptiometry-Bone Mineral Density) scan (L1-L4 spine, left and right femur).T-score # -2.5 at either or both sites considered for DEXA BMD scan as osteoporosis and between -1 and -2.5 is considered as osteopenia.Results: A total number of 206 CKD stage (3-5ND) patients were screened during the period, July 23 to July 24.The prevalence of osteoporosis was found 32.5% in overall population with 23.8% in male and 47.3% in female population; while that of osteopenia found 67.9% in overall population with 71.9% in male and 61.8% in female population.The mean T-score observed in overall population was -1.75Æ 1.38 at L1-L4 spine, -1.37Æ 0.97 left femur and -1.41Æ 0.98, right femur.In male, mean T-score was -1.42 Æ1.38 at the L1-L4 spine, -1.20Æ 0.92 left femur and -1.21Æ 0.92 right femur while in female, it was -2.31Æ 0.124 at L1-L4 (L-lumber) spine, -1.67 Æ 1.00 at left femur and -1.76Æ 0.985 at right femur.The correlation coefficient between L1-L4 spine T-score and eGFR (estimated Glomeralar Filtration Rate by CKD EPI Creatinine formula) was 0.03, with T-score left femur was 0.32 and with T-score right femur was 0.30 in the overall population.In male, the correlation coefficients were -0.01, 0.40 and 0.38 while in female, 0.13, 0.18 and 0.17 between eGFR with T-score L1-L4 spine, left femur and right femur respectively.

Source: Kidney International Reports

DOI: 10.1016/j.ekir.2024.11.247

Authors: Deepakkumar Prasad, Mahesh Prasad, Alan Almeida, Rasika Sirsat, Ayan Dey

Institution: P. D. Hinduja Hospital and Medical Research Centre

Language: English

Topic: Parathyroid Disorders and Treatments

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,800