Work

Global dynamics on a delayed double-strain influenza model with vaccination and cross-immunity

Year: 2025

Type: article

Abstract: In this paper, a delayed double-strain influenza model with vaccination and cross-immunity is proposed to explore the effect of coinfection of double-strain on disease spread. First, the nonnegativity and ultimate boundedness of solution are proved. Second, the basic reproduction numbers of strains 1, 2, and the whole model are defined respectively, by which criteria on the local and global asymptotic stability of (disease-free, dominant) equilibria are established. The uniform persistence of (strains 1, 2 coexistent) disease is obtained as well. Finally, the validity of the theoretical results is demonstrated by numerical simulations. We find that neglecting cross-immunity and vaccination would misestimate the size of influenza outbreaks. Cross-type multivalent vaccines will be the main direction for effective control measure for influenza.

Source: Advances in Continuous and Discrete Models

DOI: 10.1186/s13662-025-03886-z

Authors: Shukun Gao, Long Zhang, Hongli Li, Zhidong Teng

Institutions: Xinjiang University, Xinjiang Medical University

Language: English

Topic: Mathematical and Theoretical Epidemiology and Ecology Models

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $1,890