Work

Synthesis, Modification, and In Vitro Antimicrobial Activity of 3,4-Dihydro-4,6-diaryl-2-pyrimidinethiones

Year: 2024

Type: article

Abstract: A series of 3,4-dihydro-4,6-diaryl-2-pyrimidinethiones was obtained using a three-component reaction and their modifiaction with dimethyl chloroethynylphosphonate was performed. It was shown that the phosphonylation reaction occurs under mild conditions and chemo- and regioselectively leads to bicyclic products, namely dimethyl 5,7-diaryl-5 H -thiazolo[3,2- a ]pyrimidine-3-phosphonates. Antimicrobial activity of the synthesized compounds against Staphylococcus aureus and Pseudomonas aeruginosa bacteria and yeast-like fungi Candida utilis was studied.

Source: Russian Journal of General Chemistry

DOI: 10.1134/s1070363224120077

Authors: A. S. Skrylkova, D. M. Egorov, A. S. Krylov, E. N. Chernova, I. L. Kuzikova, Z. A. Zhakovskaya

Institutions: St. Petersburg State Technological Institute, Russian Academy of Sciences

Language: English

Topic: Synthesis and Characterization of Heterocyclic Compounds

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Funder: Russian Science Foundation

Award: G7021091247