Work

Risk of adverse cardiovascular events following spinal cord injury in patients with osteoporosis: Real-world evidence

Year: 2025

Type: article

Abstract: Introduction: Spinal cord injury (SCI) is associated with increased cardiovascular risks, and cardiovascular disease (CVD) remains a leading cause of death for individuals with SCI. Osteoporosis, a condition associated with SCI, has been linked to CVD. However, the cardiovascular risk profile of individuals with SCI with osteoporosis remains unclear. Methods: 7,296 in each group). A Cox regression model was employed to estimate the hazard ratio (HR) for the primary outcomes: the development of acute myocardial infarction (AMI), atrial fibrillation (AF), or heart failure (HF). Results: Individuals with SCI with osteoporosis have a significantly higher risk of cardiovascular events (HR: 1.15, 95 % confidence interval [CI]: 1.08-1.22)-including AMI (HR: 1.17 95 % CI: 1.02-1.33), AF (HR: 1.14, 95 % CI: 1.04-1.24), and HF (HR: 1.14, 95 % CI: 1.05-1.24)-than do those without SCI. Furthermore, mortality risk is higher in individuals with SCI, particularly those with pathological fracture. Subgroup analyses based on sex and age supported these findings. Conclusion: The complex interplay between SCI, osteoporosis, and cardiovascular health underscores the requirement for comprehensive management strategies for individuals with SCI who also have osteoporosis.

Source: American Journal of Preventive Cardiology

DOI: 10.1016/j.ajpc.2025.100938

Authors: Shih-Kai Kao, Yu-Ting Yu, Ming-Hsien Tsai

Institutions: Taipei Veterans General Hospital, Shin Kong WHS Memorial Hospital, Landseed Hospital, Fu Jen Catholic University

Language: English

Topic: Spinal Cord Injury Research

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,900