Work

Oxygen-dependent functional brain haemodynamic response

Year: 2025

Type: article

Abstract: The influence of hypoxia - a condition where tissues are under oxygen deficiency - on the human brain under functional load has not been fully understood yet. This study aims to analyse the effects of hypoxia on the brain’s haemodynamic response under visual stimulation, using the in-house developed functional near-infrared spectroscopy system and to quantify the hemodynamic response. Our results (median, 25th and 75th percentile) demonstrate the amplitude of the oxygenated haemoglobin functional response during hypoxia 0.30 µM (0.27, 0.41) was lower compared with the normoxia 0.63 µM (0.54, 0.93) and hyperoxia 0.73 µM (0.43, 1.09). No statistical significance is observed for the deoxygenated haemoglobin changes. The hypoxia has a statistically significant effect on the amplitude of the haemodynamic response (p < 0.001).

Source: Biomedical Optics Express

DOI: 10.1364/boe.545722

Authors: Karolina Bejm, Stanislaw Wojtkiewicz, Zanna Pastuszak, Adam Liebert

Institutions: Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Mossakowski Medical Research Institute, Polish Academy of Sciences

Language: English

Topic: Optical Imaging and Spectroscopy Techniques

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,913