Year: 2024
Type: article
Abstract: MDA5+ DM, or anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis (DM), is a rare autoimmune illness that primarily affects women of Asian origin. The typical presentation of MDA5+ DM includes a variety of cutaneous lesions accompanied by either no muscular weakness (amyopathic) or hypomyopathic features. In patients with MDA5+ DM, rapid progression of interstitial lung disease is a frequent manifestation associated with poor prognosis. Pneumomediastinum, spontaneous intramuscular haemorrhage, and macrophage activation syndrome form a spectrum of rare manifestations associated with MDA5+ DM. Since these issues are uncommon but fatal, it's important to explore the approaches for diagnosis, treatments, and possible mechanisms, that are useful for prompt treatments and management of the patient.
Authors: Ramaswamy Subramanian, Rupal Prasad, Mamadapur Mahabaleshwar, Anjum Siddiqui, Digvijay Ekbote, Urmila Dhakad
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4406919285