Year: 2024
Type: article
Abstract: Bone metastasis (BM) accounts for about 65%–75% of metastatic breast cancer (MBC) cases. Unlike BM, symptomatic bone marrow metastasis (BMM) is uncommon in MBC. The reported incidence of BMM is only 0.17% in MBC and 0.6%–1.7% in other solid tumours such as gastric and lung cancer. The extent of bone marrow infiltration leading to BMM manifestations is varied and complex. Diagnosis of BMM primarily relies on bone marrow aspiration smears and biopsies. The lack of specific clinical signs in BMM makes early diagnosis challenging, underscoring the need for expertise in this field. Due to limited data in this area, the appropriate treatment of breast cancer with BMM is not extensively discussed in significant guidelines. Most patients with BMM have hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2−) tumours. The goal is to improve understanding of this disease and provide effective diagnostic and treatment strategies.
Author: Ruquaya Mir
Institution: Indraprastha Apollo Hospitals
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4406960376