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Effects of 100 IU versus 150 IU hCG supplementation on oocyte and embryo quality in patients aged ≥ 35 years: a propensity score-matched analysis

Year: 2025

Type: article

Abstract: Background: The optimal dose of human chorionic gonadotropin (hCG) supplementation during controlled ovarian stimulation (COS) remains controversial, particularly in women of advanced reproductive age.Objective: To compare the efficacy and safety of 150 IU versus 100 IU daily hCG supplementation from stimulation day 6 in women aged ≥ 35 years undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI).Methods: In this retrospective cohort study, we analyzed data from 438 patients aged ≥ 35 years undergoing IVF at a single center.Propensity score matching was performed at a 1:1 ratio, yielding 192 patients per group who received either 100 IU or 150 IU daily hCG supplementation from stimulation day 6 during GnRH antagonist cycles.Results: After propensity score matching, baseline characteristics were comparable between groups.The 150 IU group yielded significantly more total oocytes (9.23±6.60 vs 7.79±5.52,p<0.001).However, the number of mature oocytes (6.25±5.12vs 5.66±4.58)and day 3 embryos (5.22±4.62 vs 4.80±3.96)did not differ significantly between groups.Total FSH dose was similar (2664.84±141.91 vs 2666.02±142.51IU, p=0.936).Only one case of moderate ovarian hyperstimulation syndrome occurred in the 150 IU group.Conclusions: In women aged ≥ 35 years, while 150 IU daily hCG supplementation from stimulation day 6 safely increased total oocyte yield compared to 100 IU, it did not significantly improve mature oocyte numbers or embryo development.

Source: International Journal of Medical Sciences

DOI: 10.7150/ijms.106965