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Determinants of reverse remodeling in chronic severe aortic regurgitation: Role of myocardial hypertrophy and extracellular volume

Year: 2025
Type: article
Study design: Observational Study
Abstract: Chronic aortic regurgitation (AR) results in myocardial remodeling which is characterized by left ventricular dilatation, myocyte hypertrophy and expansion of the extracellular matrix. This study explored the potential of pre-operative myocardial remodeling to influence reverse remodeling following aortic valve replacement (AVR). Using cardiac magnetic resonance (CMR), we quantified extracellular volume fraction (ECV%) and indexed extracellular volume (iECVol), investigating their association with postoperative remodeling and exercise capacity.
DOI: 10.1016/j.jocmr.2024.101264
Authors: George D. Thornton, Nikoo Aziminia, Jonathan Bennett, Christian Nitsche, Francisco Gama, Alexander Birkinshaw, Abhishek Shetye, Michael McKenna, Leire Tapia, Iain Pierce, Dan Sado, Rhodri Davies, Arantxa Gonzalez, Peter Kellman, James Moon, Thomas Treibel
Institutions: University College London, Hospital de Santa Cruz, King's College Hospital, Universidad de Navarra, Barts Health NHS Trust, National Heart, Lung, and Blood Institute
Language: English
Field: Medicine
Open Access status: gold
Estimated APC paid: $3,000
OpenAlex ID: W4406972284
FWCI:
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