Year: 2024
Type: article
Abstract: Albumin serves as a compelling carrier in nanomedicine because of its distinctive characteristics. Initially, it stands as the predominant protein found in blood, which contributes to its high compatibility, biodegradability, and safety for clinical applications. The structure facilitates interaction with various pharmaceuticals, aiding in their protection from metabolic degradation and enhancing their efficacy. Furthermore, albumin has the capability to bind to receptors commonly present in pathological tissues, facilitating direct delivery to the impacted regions without the necessity for additional targeting agents.Albumin possesses a half-life of approximately 19 days in the bloodstream, which facilitates the prolongation of drug action and enhances their delivery to target sites with precision. This article highlights the significance of albumin in drug delivery systems, particularly for hydrophobic drugs, employing both passive and active targeting mechanisms. The text examines the advanced NAB Technology and the advantages of Nab-Paclitaxel (Abraxane) in relation to conventional formulations such as CrEL-paclitaxel (Taxol). It emphasizes the function of albumin in the transport of anticancer medications, concentrating on formulations that are presently undergoing clinical trials. The article highlights the capabilities of albumin as a natural drug delivery system and its importance in enhancing drug efficacy within the body.
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4406975958