Year: 2025
Type: review
Abstract: The prevalence of breast cancer among women has led to a growing need for innovative anti‑breast cancer medications and an in‑depth investigation into their molecular mechanisms of action, both of which are essential tactics in clinical intervention. In the clinical practice of Traditional Chinese Medicine, Radix Bupleuri and its active components have shown promise as potential anti‑breast cancer agents due to their ability to target multiple pathways, exhibit synergistic effects and reduce toxicity. These compounds are considered to enhance the prognosis of patients with cancer, prolong survival and combat chemotherapy resistance. The present review aimed to delve into the anti‑breast cancer properties of Radix Bupleuri and its active ingredients, highlighting their mechanisms, such as inhibition of cell proliferation, promotion of apoptosis, metastasis prevention, microenvironment improvement and synergy with certain chemotherapeutic agents. These findings may provide a scientific rationale for combining Radix Bupleuri and its active components with traditional chemotherapy agents for the management of breast cancer.
Source: Oncology Letters
Authors: Shiting Jiang, Chengxia Li, Dan Liu, Fancai Zeng, Wenli Wei, Tao He, Wenli Yang
Institution: Southwest Medical University
Language: English
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Funder: Southwest Medical University
Award: G2406090054
OpenAlex ID: W4406990089