Work

Cerebral Edema in Children and Adolescents with Diabetic Ketoacidosis: Pathophysiological Mechanisms and Clinical Presentation

Year: 2024

Type: article

Abstract: INTRODUCTION: Diabetic ketoacidosis (DKA) is one of the acute and severe complications of type 1 diabetes mellitus in pediatric practice. AIM: To analyzed based on literature data the key pathophysiological mechanisms and clinical features of cerebral edema (CE) in children and adolescents with DKA. The paper describes the results of foreign and domestic studies dedicated to the mechanisms of development, clinical features of CE in pediatric practice. Topic-related sources from the PubMed and RSCI databases are reviewed. The search depth is 25 years. CONCLUSION: Reviewed are the pathogenetic mechanisms underlying the development of cytotoxic, vasogenic and osmotic CE. Particular emphasis is made on the inflammation theory and the role of ischemic/hypoxic factors in the development of CE. Data are provided to describe specific clinical features of CE in children and adolescents receiving intensive care, as well as risk factors that predispose to the development of this complication. Understanding of the pathogenetic mechanisms, clinical signs CE will result in better treatment outcomes and bring down the risk of death in this category of patients.

Source: Nauka molodykh (Eruditio Juvenium)

DOI: 10.23888/hmj2024124664-672

Authors: Yuriy V. Bykov, Aleksandr N. Obedin, Vasiliy V. Fischer, Evgeniy V. Volkov, Ivan V. Yatsuk

Institution: Stavropol State Medical University

Language: English

Topic: Diabetes Management and Research

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4406990839