Work

Effects of Porphyromonas gingivalis Outer Membrane Vesicles ( OMVs ) on Macrophages in Periodontitis

Year: 2025

Type: article

Abstract: OBJECTIVE: To review the effect of outer membrane vesicles (OMVs) of the periodontal pathogen Porphyromonas gingivalis (P. gingivalis) on macrophages during periodontitis development. METHOD: Literature pertaining to P. gingivalis OMVs and macrophages was reviewed and discussed, with a focus on the immunomodulatory effects of P. gingivalis OMVs on macrophages. RESULTS: P. gingivalis OMVs affect the recognition, phagocytosis, polarization, and apoptosis functions of macrophages. However, information on their antigen-presenting effect remains lacking, and further research is required for clinical applications. CONCLUSION: P. gingivalis OMVs can influence the development of periodontitis through immune modulation of macrophages; however, further research is required to provide novel ideas for the prevention and treatment of periodontitis.

Source: Oral Diseases

DOI: 10.1111/odi.15264

Authors: Shuyi Zhang, Yao Jiao, Siyan Liu, Yitong Liu, Yi Liu

Institution: Capital Medical University

Language: English

Topic: Oral microbiology and periodontitis research

Subfield: Periodontics

Field: Dentistry

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze