Work

CRISPR-based epigenetic editing of Gad1 improves synaptic inhibition and cognitive behavior in a Tauopathy mouse model

Year: 2025

Type: article

Abstract: lentiviruses had significantly elevated GABAergic synaptic currents and improved spatial memory. These results have provided an epigenetic editing-based gene-targeting strategy to restore synaptic inhibition and cognitive function in AD and related disorders.

Source: Neurobiology of Disease

DOI: 10.1016/j.nbd.2025.106826

Authors: Lei Wan, Ping Zhong, Pei Li, Yong Ren, Wei Wang, Mingjun Yu, Henry Y. Feng, Zhen Yan

Institution: University at Buffalo, State University of New York

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,180

Funders: National Institutes of Health, National Institute on Aging

Awards: New Treatment Strategy for Alzheimer’s Disease, G3513132589, G8670275043, G9000082090

OpenAlex ID: W4407024160

FWCI: 6.891

Cites: 63

Cited by: 13

Related to: 10