Figure 6 from Targeting Pancreatic Cancer Cell Stemness by Blocking Fibronectin-Binding Integrins on Cancer-Associated Fibroblasts
Year: 2025
Type: other
Abstract: BsAb treatment reduces the fibrotic effect of human CAFs co-injected with tumor cells. A–D, BsAb-treated tumors contain less CAF-produced FN, fibrosis, and angiogenesis. Serial formalin-fixed, paraffin-embedded sections of tumors were processed for IHC detection of hFN (A) or CD31 (D), shown in brown. Mason's trichrome (B) and picrosirius red (PSR; C) histologic stains were used to visualize COL. Graphs depict the quantification of IHC staining using QuPath, with each dot representing the mean value for each tumor slice examined. P values were computed using the Student t test.
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4407037932