Work

The mechanism of acetyl-CoA synthase through the lens of a nickel model system

Year: 2025

Type: article

Abstract: Given the urgent need to develop new methods of CO2/CO utilization, understanding the mechanism of acetyl-CoA synthase is crucial. Herein, the authors report a functional model system for this enzyme that supports several proposed organometallic intermediates and promotes all key reaction steps during catalysis: methylation, carbonylation, and thiolysis.

Source: Nature Communications

DOI: 10.1038/s41467-025-60163-z

Authors: Shounak Nath, Leonel Griego, Liviu M. Mirica

Institution: University of Illinois Urbana-Champaign

Language: English

Topic: Metalloenzymes and iron-sulfur proteins

Subfield: Renewable Energy, Sustainability and the Environment

Field: Energy

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $6,990

Funders: National Science Foundation, University of Illinois at Urbana-Champaign, Division of Chemistry