Editorial: Respiratory dysfunction in neurological disease and injury: novel mechanisms and potential therapeutics
Year: 2025
Type: editorial
Abstract: Understanding the intricate mechanisms governing respiration is pivotal for addressing the diverse and complex conditions that disrupt this essential function. Over the past two decades, significant advancements in our understanding of respiratory networks have opened new avenues for discovery, enabling a deeper exploration of diseases with overlapping etiologies and trajectories and promoting a deeper appreciation of relationships between neurological, developmental, and injury-induced respiratory dysfunction. With a focus on control of breathing, this Research Topic was developed and organized to highlight recent advances in various neurological-and injury-based models for respiratory dysfunction, emphasizing mechanisms of dysfunction and potential therapeutic approaches aimed at ameliorating dysfunction.Understanding basic neural circuit connectivity that regulates respiratory (dys)function is an essential first step. While brainstem nuclei have long been recognized as central components of respiratory maintenance, additional CNS sites have recently been implicated in higher-level modulation. In the review by Trevizan-Baú, et al., the authors explore the role of the amygdala, a key brain region in the temporal lobe, in regulating respiratory functions, including breathing, swallowing, coughing, airway smooth muscle contraction, and mucus secretion (Trevizan-Baú et al. 2024). The article also examines how amygdala dysfunction may contribute to respiratory and airway pathologies, such as those seen in anxiety disorders and airway diseases.Beyond the basic circuitry involved, mechanistic insights and therapeutic approaches necessitate discovery in the disease state. In the study by Barok et The authors declare that the research was conducted in the absence of any commercial or financial 115 relationships that could be construed as a potential conflict of interest. 116
Source: Frontiers in Physiology
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4407045599