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Effect of CpG Site -123 Methylation in HOTAIR Promoter on DNMT3A Binding and Transcriptional Silencing in Endometrial Cancer

Year: 2024

Type: article

Abstract: Endometrial cancer is a common malignancy with significant epigenetic alterations, particularly involving DNA methylation. The long non-coding RNA HOTAIR regulates gene expression through epigenetic mechanisms. This review investigates the specific impact of methylation at CpG site -123 within the HOTAIR promoter region on DNMT3A binding and the effects on transcriptional silencing. Understanding these interactions provides insights into HOTAIR’s epigenetic regulation and highlights potential therapeutic targets for endometrial cancer.

Source: International Journal of Newgen Research in Pharmacy & Healthcare

DOI: 10.61554/ijnrph.v2i2.2024.96

Authors: Hrithik Dey, Harshita Mathur, Neel Chatterjee, Ruchi Jadon

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4407049447

FWCI:

Cites: 16

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Related to: 10