Biological pathways underlying the relationship between childhood maltreatment and Multimorbidity: A two-step, multivariable Mendelian randomisation study
Year: 2025
Type: article
Study design: Observational Study
Abstract: = 156,717), we tested for the presence of an indirect effect via each mediator individually. We found a potential role of metabolic pathways. Up to 11% of the effect of childhood maltreatment on multimorbidity was mediated by triglycerides (indirect effect [95% CI]: 0.018 [0.009-0.027]), 8% by glycated haemoglobin (indirect effect: 0.013 [0.003-0.023]), and up to 7% by high-density lipoprotein cholesterol (indirect effect: 0.011 [0.005-0.017]). We did not find evidence for mediation via any inflammatory protein or cortisol. Our findings shed light on the biological mechanisms linking childhood maltreatment liability to multimorbidity, highlighting the role of metabolic pathways. Future studies may explore underlying pathways via non-biological mediators (e.g., lifestyle factors) or via multiple mediators simultaneously.
Source: Brain Behavior and Immunity
Language: English
Topic: Child Abuse and Trauma
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: hybrid
Estimated APC paid: $5,680
Awards: G1067152967, Running in the FAMILY - Understanding and predicting the intergenerational transmission of mental illness, G2606538822, G3725605721, An Integrated Life-Course Approach for Person-Centred Solutions and Care for Ageing with Multi-morbidity in the European Regions - STAGE; Stay Healthy Through Ageing, G434337789, G4446146903, Understanding, predicting, and treating depression in pregnancy to improve mothers and offspring mental health outcomes, G5508677496, G8074060860
OpenAlex ID: W4407054268