Work

Higher level of [3H]UCB-J binding in ApoE Ɛ4 allele carriers with Alzheimer disease

Year: 2025

Type: article

Abstract: H]UCB-J was found to be reduced in frontal cortex from patients with AD. We report here that the reduction in SV2A binding is highly significant only in patients not carrying the ApoE ɛ4 allele. By contrast, those individuals with one or two ApoE ɛ4 alleles had SV2A binding levels not different from controls. Because ApoE4 is an important genetic risk and strongly linked to late-onset AD, this study raises an interesting new and unexpected association to SV2A, synapse loss, and function.

Source: Neuroscience Letters

DOI: 10.1016/j.neulet.2025.138135

Authors: Jens D. Mikkelsen, Phoebe Linde-Atkins, Burcu A. Pazarlar

Institutions: University of Copenhagen, Copenhagen University Hospital, Rigshospitalet

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,430