Work

Design and synthesis of triazole sulfonamide inhibitors of bc1 complex

Year: 2025

Type: article

Abstract: Currently, triazole sulfonamide fungicide could be used to effectively control cucumber downy mildew (CDM), caused by Pseudoperonospora cubensis. In this study, a series of triazole sulfonamide derivatives containing diphenyl ether (DE) fragment were designed and synthesized. All target compounds were evaluated for their fungicidal activity against four oomycete diseases. Compound 10b showed the best activity against CDM with 40% control efficacy at 0.78 mg/L, which was the same as amisulbrom. Meanwhile, compounds 10d and 10h showed good inhibitory activity against Peronophythora litchii and compounds 10e, 10f, 10l and 10q showed good inhibitory activity against Phytophthora infestans. The results of computational chemistry showed that compound 10b had the same binding mode as amisulbrom and formed hydrogen bonds with the residues Gln9, His189 and Ash217. Compound 10b could be further investigated as a potential fungicide candidate. This study also provides a useful optimization strategy for the design of novel fungicides to against CDM.

Source: Advanced Agrochem

DOI: 10.1016/j.aac.2025.01.003

Authors: Ying Dong, Jun-Chao Zhang, Jia-Yue Sun, Ze-Wei Guan, Guang-Kai Yao, Xiao-Lei Zhu

Institutions: Central China Normal University, South China Agricultural University

Language: English

Topic: Fungal Plant Pathogen Control

Subfield: Ecology, Evolution, Behavior and Systematics

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Zero hunger

Open Access status: diamond

Funders: National Natural Science Foundation of China, South China Agricultural University, National Key Research and Development Program of China