Work

NFAT single-deficient murine T cells reduce the risk of aGvHD while controlling cytomegalovirus infection

Year: 2025

Type: article

Abstract: inflated memory T cells expanded more and with higher levels of interferon gamma (IFN-γ) and GzmB expression, effectively controlling CMV. Notably, NFAT-deficient inflated memory T cells could migrate to non-lymphoid tissues and fight CMV. Therefore, CMV infection does not interfere with the protective effect of NFAT inhibition to attenuate GvHD while allowing an anti-CMV response.

Source: iScience

DOI: 10.1016/j.isci.2025.111937

Authors: Nadine Hundhausen, Snigdha Majumder, Yin Xiao, Sigrun S. Haeusl, Helen Goehler, Rishav Seal, Cristina M. Chiarolla, Andreas Rosenwald, Matthias Eyrich, Luka Cicin-Sain, Friederike Berberich-Siebelt

Institutions: University of Würzburg, Comprehensive Cancer Center Mainfranken, Universitätsklinikum Würzburg, Helmholtz Centre for Infection Research, Centre for Individualised Infection Medicine

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240

Funders: Deutsche Forschungsgemeinschaft, Deutsche Krebshilfe

Awards: G101308371, G1615103949, G2830669520, G2974754072, G357496357, G3818521042, G5589951031, TRR 221: Steuerung der TransplantatgegenWirt und TransplantatgegenLeukämieImmunreaktionen nach allogener Stammzelltransplantation

OpenAlex ID: W4407056296

FWCI: 0.295

Cites: 77

Cited by: 1

Related to: 10