Work

Omadacycline for the Treatment of Severe Legionella Pneumonia Complicated with Multiple Organ Failure: A Case Report

Year: 2025

Type: article

Abstract: Background: Fluoroquinolones and macrolides are the preferred antibiotics for treating Legionnaires’ disease. However, the limited utility of these antibiotics in cases of organ dysfunction is a major problem. Omadacycline is a novel tetracycline antibiotic with a good safety profile and in vitro antibacterial activity against Legionella , but it lacks validation by clinical data. Case Description: Here, we report a case of severe pneumonia caused by Legionella infection. The patient was empirically treated with antibiotics, after admission but had a poor clinical outcome with severe hepatic and renal insufficiency. After Legionella infection was confirmed by metagenomic next-generation sequencing, the patient was switched to omadacycline antibiotic therapy and eventually discharged after recovery. Conclusion: Th e results of this study suggest that metagenomic next-generation sequencing can facilitate early diagnosis of Legionnaires’ disease, and omadacycline can be an alternative antibiotic treatment for severe Legionnaires’ disease, especially in patients experiencing multiple organ failure. Keywords: Legionella pneumonia, Legionnaires‘disease, metagenomic next-generation sequencing, omadacycline, antibiotic therapy

Source: International Medical Case Reports Journal

DOI: 10.2147/imcrj.s498539

Authors: Limin Xu, Ying Xiong, Changquan Fang

Institution: Huizhou Central People's Hospital

Language: English

Topic: Legionella and Acanthamoeba research

Subfield: Endocrinology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,320