Year: 2024
Type: article
Abstract: Introduction:The indigenous population of Nagaland has traditionally utilized the bark of Mahonia napaulensis as a remedy for gastrointestinal ailments; however, its therapeutic effectiveness has not been scientifically verified.The objective of the current investigation is to assess the efficacy of the methanolic bark extract of M. napaulensis in promoting the healing of peptic ulcers. Methods:The study involved the induction of ulcers in Swiss albino mice via the oral administration of a single dose of 80% ethanol (1 ml/100g body weight).The effect of the methanolic bark extract of the plant on ethanol-induced peptic ulcer was studied using repeated dosing of 200 mg/kg body weight for ten and fourteen days, respectively.The standard drug utilized in the study was Ranitidine (30 mg/kg body weight).The assessment of ulcer healing activity was conducted through the evaluation of various parameters, including the ulcer index, healing percentage, gross macroscopic lesions, as well as histopathological and ultrastructural observations.The concentrations of malondialdehyde (MDA), glutathione (GSH), protein, and sialic acid were quantified. Results:The results indicate that the oral consumption of methanolic bark extract of M. napaulensis has pro-healing efficacy on ulcerated mice.Thus, this justifies the use of the plant as a healing agent among the rural population. Conclusion:The results indicate that the oral consumption of methanolic bark extract of M. napaulensis has pro-healing efficacy on ulcerated mice.Thus, this justifies the use of the plant as a healing agent among the rural population. www.phypha.ir/ppj Experimental Research ArticlePhysiology and Pharmacology 28 (2024) 440-452 Peptic ulcer disease (PUD) is one of the most common diseases in the world.It is mostly caused by two factors: persistent Helicobacter pylori infection and non-steroidal anti-inflammatory drugs (NSAIDs) misuse (Kavitt et al., 2019).Besides that, excessive alcohol or caffeine consumption, unhealthy diets, smoking habits, and men-tal stress are also key contributors to the development of peptic ulcer disease (Ahmad et al., 2019;Tripathi et al., 2021).For evaluation of anti-peptic ulcer potential, one of the most commonly used experimental models is the ethanol-induced ulcer model which closely resembles the physiological and morphological alterations observed in acute human peptic ulcer disease (Fu et al.,
Source: Physiology and Pharmacology
Authors: Sanchayeeta Roy, Deepjyoti Dev, Bishnupada Roy
Institution: North Eastern Hill University
Language: English
Topic: Medicinal Plant Research
Subfield: Plant Science
Domain: Life Sciences
Open Access status: hybrid
Funder: North-Eastern Hill University
OpenAlex ID: W4407065357