Work

A network aggregation model for amyloid-$$\beta $$ dynamics and treatment of Alzheimer’s diseases at the brain scale

Year: 2025

Type: article

Abstract: Neurodegenerative diseases are associated with the assembly of specific proteins into oligomers and fibrillar aggregates. At the brain scale, these protein assemblies can diffuse through the brain and seed other regions, creating an autocatalytic protein progression. The growth and transport of these assemblies depend on various mechanisms that can be targeted therapeutically. Here, we use spatially-extended nucleation-aggregation-fragmentation models for the dynamics of prion-like neurodegenerative protein-spreading in the brain to study the effect of different drugs on whole-brain Alzheimer's disease progression.

Source: Journal of Mathematical Biology

DOI: 10.1007/s00285-024-02179-5

Authors: Georgia S. Brennan, Alain Goriely

Institution: University of Oxford

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,090