Year: 2024
Type: article
Abstract: Oral submucous fibrosis (OSMF) is a potentially cancerous disorder that affects the oral mucosa and causes a range of symptoms and limitations in function. Assessing the function of oral alpha lipoic acid (AL-A) as a therapy for OSMF is, therefore, intriguing. Fifty patients with OSMF symptoms were evaluated both before and after treatment. They were split into two groups: group A, which served as the control, received 1 ml SI of thioacetamide (TAA) and 1500 IU of hyaluronidase (HYAL) weekly along with the oral antioxidant α-lipoic acid for three months. Group B, which served as the case study, also received 3 months of SI of TAA and HYAL. Patients in group B were recalled for a clinical examination using a vernier caliper (VC), and visual analog scale (VAS) and fibrous bands (FB) were assessed at the 1st, 3rd, and 6th month. We discovered that controls had a comparable distribution pattern across visits when compared to the case. Treatment with AL-A in conjunction with IL-I of TAA and HYAL significantly reduced the severity of symptoms, especially Burning Sensation (BS) and mouth opening (MO), in the case group over time, as previously determined.
Source: Bioinformation
Authors: AK Shafeem Khan, Vikas Kulkarni, Abhay D. Havle
Language: English
Subfield: Periodontics
Field: Dentistry
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4407066686