Year: 2024
Type: article
Study design: Systematic Review
Abstract: Objective: This integrative review aims to synthesize and critically analyze the current literature on the use of stem cells in the treatment of pseudarthrosis. Methods: A systematic search was conducted in electronic databases, resulting in the inclusion of preclinical and clinical studies that investigated the impact of stem cells on bone healing. Results: Proposed biological mechanisms include the ability of stem cells to promote osteogenic differentiation and secrete growth factors that facilitate tissue repair. Results indicate that stem cell treatment often increases rates of successful bone healing, improving functional outcomes and reducing postoperative complications. Limitations include the heterogeneity in treatment protocols and the need for randomized clinical trials to robustly validate these findings. Conclusion: The use of stem cells emerges as a promising approach in the management of pseudarthrosis, promoting a new perspective in orthopedic regenerative medicine. Level of evidence V; Expert Opinion.
Source: Journal of the Foot & Ankle
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4407069090