Regenerable LMR-based fiber optic immunosensor with a SnO2 metallic oxide thin film for label-free detection
Year: 2025
Type: article
Abstract: This paper introduces the fabrication and characterization of a regenerable LMR-based, label-free optical fiber immunosensor. This innovative biosensor proposal was developed by functionalizing a SnO 2 metallic oxide thin film deposited on a D-shaped optical fiber using a silanization protocol. The system successfully detected IgG - anti-IgG complexes in real-time in a range of concentrations from 0.5 to 10 μg/ml and achieved a limit of detection (LoD) of 0.12 μg/ml of anti-IgG. The biosensor was extensively tested to assess its capacity for regeneration, confirming that it can be reused repeatedly, reducing the overall cost and waste typically associated with disposable sensors. This regenerability has significant implications for a range of applications, providing a more sustainable and flexible approach to biosensing technology. • Novel silanization-based functionalization for D-shaped LMR optical fibers. • Regenerable biosensor detects anti-IgG with 0.12 μg/mL limit of detection. • Reusable design enhances cost-efficiency and reduces biosensor waste. • Reliable biomolecule detection across specific and non-specific interactions.
Source: Talanta
Language: English
Topic: Advanced Fiber Optic Sensors
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,610
OpenAlex ID: W4407069538