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Biointerface‐Engineered Hybrid Nanovesicles for Targeted Reprogramming of Tumor Microenvironment (Adv. Mater. 41/2024)

Year: 2024

Type: article

Abstract: Hybrid Biointerface Engineering In article number 2401495, Wei Tao, Sicen Wang, Xiaoyu Xie, and co-workers present a novel biointerface-engineered hybrid nanovesicle (P-I@M1E/AAL), achieved by integrating M1-like macrophage-derived exosomes with AS1411 aptamer-conjugated liposomes. The designed P-I@M1E/AAL nanoplatform combines multiple treatment modalities, offering a promising therapeutic approach to overcome the challenges of the hypoxic and immunosuppressive tumor microenvironment. By reprogramming tumor-associated macrophages and enhancing tumor-targeted photodynamic-immunotherapy, this platform shows significant potential for improving anti-tumor treatment outcomes.

Source: Advanced Materials

DOI: 10.1002/adma.202470327

Authors: Xueyan Zhen, Yongjiang Li, Wanqing Yuan, Tingting Zhang, Min Li, Jinhai Huang, Na Kong, Xiaoyu Xie, Sicen Wang, Wei Tao

Institutions: Brigham and Women's Hospital, Harvard University, Xi'an Jiaotong University, Chinese Academy of Medical Sciences & Peking Union Medical College, Fudan University, Eye & ENT Hospital of Fudan University, Tibet University

Language: English

Topic: Nanoplatforms for cancer theranostics

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4407083984

FWCI:

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