Evaluating the research parameters available on the Sysmex® XN-series hematology analyzers as markers of dysplasia in peripheral blood
Year: 2025
Type: article
Study design: Observational Study
Abstract: Objectives: hematology analyzers, including immature platelet fraction (IPF), Neutrophil Granularity Index (Neu-GI), or platelet distribution width (PDW), show a relationship with dysplasia in peripheral blood. The objective of this study was to examine the association between classic and research blood count parameters and the presence of dysplasia. The secondary objective was to develop a multivariate model that allows the prediction of dysplasia with high probability. Methods: Seventy-five patients older than 60 years with anemia, leukopenia or thrombocytopenia, without vitamin B12 and folate deficiency or hematological diseases underwent testing with the Sysmex XN-1000 analyzer. Results: Dysplasia was confirmed in 32 % of patients, with significant differences in Neu-GI, PDW and IPF count between the groups of patients with and without dysplasia. Neu-GI was the parameter with the highest predictive value (AUC=0.98), with such value not increasing significantly after the addition of PDW or PIF. A Neu-GI value≤146ch predicts dysplasia with a positive predictive value=90 %. Conclusions: Neu-GI is the parameter most strongly associated with dysplasia. A Neu-GI value≤146ch indicates a high probability of dysplasia and supports indication for a blood smear review. Additionally, values>152ch indicate a low probability of dysplasia.
Authors: Vicente Aguadero, María López, Míriam Ruíz, Diana Regidor, Gemma Celma
Institution: Hospital de Sant Joan Despí Moisès Broggi
Language: English
Subfield: Emergency Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4407086104