Work

Radiological and clinical differential diagnostics of CPPD in the temporomandibular joint extending into the cranium: Insights from the literature and a rare clinical case

Year: 2025

Type: article

Abstract: Calcium pyrophosphate deposition disease (CPPD) in the temporomandibular joint (TMJ) is rare but occasionally appears locally destructive. Various radiological techniques are available for differential diagnosis. We present the case of a 66-year-old man with long-standing, painful, unilateral TMJ swelling. Radiological imaging showed a mass with calcifications, erosion of the articular roof and invasion of the middle cranial fossa. Differential diagnoses included CPPD, tenosynovial giant cell tumor, synovial chondromatosis, chondrosarcoma, and osteochondroma. A biopsy confirmed CPPD, followed by resection of the lesion and immediate TMJ reconstruction with a patient-specific prosthesis. Benign and malignant TMJ lesions extending into the cranium are uncommon and their radiological differentiation remains challenging. Therefore, we performed a scoping review focusing on TMJ imaging allowing differential diagnosis of CPPD. • Radiologically differentiating tumors of the temporomandibular joint is challenging. • Benign tumors of the temporomandibular joint extending into the cranium are rare. • Calcium PyroPhosphate Deposition disease can be locally destructive in the TMJ. • CBCT and MRI commonly used in radiological differentiation and surgical planning.

Source: Oral Oncology Reports

DOI: 10.1016/j.oor.2025.100716