Altered thermal preference by preoptic estrogen receptor alpha neurons in postpartum females
Year: 2025
Type: article
Abstract: OBJECTIVE: This study aims to investigate how reproductive experience (RE) alters thermal preference and thermoregulation in female mice, with a focus on estrogen receptor alpha (ERα)-expressing neurons in the preoptic area (POA). METHODS: ) were assessed using immunohistochemistry and in vitro electrophysiology in response to temperature changes and ERα agonist. RESULTS: neurons were slightly enhanced in female mice with RE. CONCLUSION: neurons are regulated by reproductive experience, altering thermal preference.
Source: Molecular Metabolism
Authors: Nan Zhang, Meng Yu, Qianru Zhao, Bing Feng, Yue Deng, Jonathan C. Bean, Qingzhuo Liu, Benjamin P. Eappen, Yang He, Kristine M. Conde, Hailan Liu, Yongjie Yang, Longlong Tu, Mengjie Wang, Yongxiang Li, Na Yin, Hesong Liu, Junying Han, Darah Ave Threat, Nathan Xu, Taylor Smiley, Pingwen Xu, Lulu Chen, Tianshu Zeng, Yanlin He, Chunmei Wang
Institutions: Baylor College of Medicine, Children's Nutrition Research Center at Baylor College of Medicine, Huazhong University of Science and Technology, Pennington Biomedical Research Center, Louisiana State University, South Central Minzu University, University of Illinois Chicago, Wuhan Union Hospital
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,270
Awards: G385540613, G6874135152, G8810989103
OpenAlex ID: W4407087916