Work

Primary Breast Lymphoma in a Young Female: Non-Hodgkin’s Diffuse Large B-Cell Lymphoma in the Presence of Intact Breast Prostheses

Year: 2025

Type: article

Abstract: Introduction: Primary breast lymphoma (PBL) is a rare non-Hodgkin lymphoma, predominantly presenting as diffuse large B-cell lymphoma (DLBCL) and primarily affecting the breast, often misdiagnosed due to its nonspecific symptoms resembling breast carcinoma. Breast implants are among the most frequently used medical devices for esthetic and reconstructive purposes. Case Presentation: We present a 24-year-old female with a growing breast mass who was diagnosed with PBL (non-Hodgkin's DLBCL). She underwent successful R-CHOP chemotherapy, resulting in complete remission. Follow-up imaging showed no distant metastasis or significant residual disease, with silicone implants intact and no pathological uptake. Conclusion: PBL is a rare malignancy that primarily affects postmenopausal women, with diagnosis relying on radiologic investigations and histopathology due to its clinical and imaging similarities to breast carcinoma. Treatment is controversial and often involves rituximab-based chemotherapy, intrathecal methotrexate, and radiotherapy, with improved outcomes observed in recent years.

Source: Case Reports in Oncology

DOI: 10.1159/000543952

Authors: Ahmad Al-Bitar, Amnah Zahreddin, Mohammed Shwin, Abdullah Barbar, Alaa Dirani

Institutions: Damascus University, Damascus Hospital

Language: English

Topic: Lymphoma Diagnosis and Treatment

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,170