Year: 2025
Type: article
Abstract: The development of catalytic PIII/PV=O redox processes has transformed the Wittig reaction, traditionally plagued by stoichiometric phosphine oxide byproducts, into an efficient and more benign method for synthesizing alkenes. Recently, the feasibility of enantioselective PIII/PV=O redox catalysis was demonstrated by using chiral phosphine catalysts, such as HypPhos. For example, an atroposelective Wittig reaction using Boc-MBH adducts, where endogenous base release facilitates ylide formation and acid co-catalysis, allows enantiocontrol and effective PIII/PV=O redox cycling, while catalyst-stereocontrolled enantioselective Wittig reactions generally extend the scope and sustainability of the synthesis of complex molecules. 1 Introduction 2 meso-Desymmetrizations 3 Atroposelective Catalysis 4 Conclusion
Source: Synlett
Authors: Christof Sparr, Kalipada Jana
Institutions: University of Basel, Thieme Medical Publishers (Germany)
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Awards: G2833086786, G434337789
OpenAlex ID: W4407095756