Work

The effect of Mediterranean diet and high-intensity interval training on inflammatory markers in obese and overweight premenopausal women: A controlled trial

Year: 2025

Type: article

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: Background We aimed to investigate the effect of eight weeks of Mediterranean Diet (MedDiet) and high-intensity interval training (HIIT) on inflammatory markers in obese and overweight premenopausal women. Methods In this trial, 47 overweight and obese women were randomly divided into 4 groups: MedDiet group without calorie restriction (n = 14), HIIT group (n = 12), MedDiet + HIIT group (n = 12), and control group (n = 9). HIIT training sessions were carried out for 8 weeks, 3 sessions per week. In HIIT group, participants were instructed to maintain their usual diet. The participants in MedDiet program and Med Diet + HIIT groups were instructed to follow the principal aspects of MedDiet without caloric restriction. The serum level of IL-6 and adiponectin were measured using ELISA kits and serum CRP concentrations were determined by Turbidometery. Results The results showed that HIIT had no effect on the studied indices. Furthermore, MedDiet and HIIT together significantly increased the serum level of interleukin-6 ( P = 0.00). While there were no significant changes in CRP ( P = 0.72) and adiponectin ( P = 0.16) between the groups at the end of the study. Conclusion Taken together, the results of this study demonstrated that a combination of the MedDiet and HIIT can be associated with a significant increase in IL-6. However, the current findings did not support alteration in adiponectin and CRP.

Source: Clinical Nutrition Open Science

DOI: 10.1016/j.nutos.2025.01.006

Authors: Mohammadreza Rabiee, Razieh Hosseini, Raziye Tahmasebi, Maryam Koushkie Jahromi, Sasan Amanat

Institutions: Shiraz University, Shiraz University of Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Lorestan University of Medical Sciences

Language: English

Topic: Nutritional Studies and Diet

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,200