Work

Chemical components of Salvia cavaleriei and their anti-inflammatory effect via NF-κB signaling pathway

Year: 2025

Type: article

Abstract: In this study, with the aimed to explore the anti-inflammatory ingredients of Salvia cavaleriei , a phytochemical study with bioactive guided isolation for this plant have been taken. As a result, two pairs of new phenylacetic acid enantiomers , (±) cavalvia A (± 1 ) and B (± 2 ), and one previously undescribed germacrane-type sesquiterpenoid , salviesquiten A ( 3 ), along with ten known ones ( 4 – 13 ) were isolated from the ethyl acetate portion of 95 % ethanol extract. Their chemical structures were established based on UV, IR, MS and NMR spectroscopic analyses , as well as PD4 + probability analysis and electronic circular dichroism (ECD) methods. Anti-inflammatory bioassay showed that compound 6 exhibited significant effect against LPS-induced NO production in the RAW264.7 macrophages model, with the IC 50 value of 3.40 ± 0.24 μM. Furthermore, compound 6 significantly suppressed the production of pro-inflammatory cytokines (IL-6, IL-1 β , and TNF- α ) and the protein expression of the enzymes iNOS and COX-2 in a concentration-dependent manner. And further investigation showed that 6 exerts anti-inflammatory effect via NF-κB signaling pathway.

Source: Fitoterapia

DOI: 10.1016/j.fitote.2025.106406