Controlled Quantum Well Formation on DNA-Wrapped Carbon Nanotubes via Peroxide-Mediated Aryl Diazonium Reduction
Year: 2025
Type: article
Abstract: Quantum well defect-modified single walled carbon nanotubes are environmentally sensitive nanomaterials with wide-ranging applications in biosensing, imaging, light harvesting, quantum computing, energy storage and catalysis. The most common method for covalent functionalization of nanotubes for biosensing applications involves reactions with aryl diazonium salts to generate sp3 aryl defect sites, commonly followed by wrapping with single stranded DNA. We describe herein a rapid aryl diazonium functionalization reaction directly compatible with DNA-wrapped nanotubes. The reaction uses mild aqueous conditions at physiological pH and can be easily monitored in real-time via fluorescence analysis to control the degree of functionalization. Overall, this reaction greatly simplifies the production of covalently functionalized DNA-wrapped carbon nanotubes, expanding their potential for industrial and biomedical applications.
Source: Nano Letters
Language: English
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Open Access status: green
Funders: National Science Foundation, Honorable Tina Brozman Foundation, Memorial Sloan-Kettering Cancer Center, Ovarian Cancer Research Alliance, Commonwealth Foundation for Cancer Research Foundation, Ara Parseghian Medical Research Fund, Expect Miracles Foundation, National Cancer Institute, National Institute of Biomedical Imaging and Bioengineering, Congressionally Directed Medical Research Programs
Awards: DMREF: DNA-Nanocarbon Hybrid Materials for Perception-Based, Analyte-Agnostic Sensing, Implantable Nanosensor for Early-Stage Ovarian Cancer Detection, G547711154, CAREER: A Quantitative Nanosensor to Measure Redox Potential in Living Systems, Cancer Center Support Grant, Nanosensor Array Platform to Capture Whole Disease Fingerprints
OpenAlex ID: W4407102148