Cytotoxicity and molecular docking analysis of phytochemicals from Vallisneria spiralis with protein target 3CZH in breast cancer management
Year: 2024
Type: article
Abstract: This research article investigates the anticancer potential of Vallisneria spiralis Linnaeus (Vallisneria spiralis L.) for human breast cancer management. The in vitro experiments demonstrated that increasing concentrations of Vallisneria spiralis silver nanoparticles (AgNPs) and iron oxide nanoparticles (IONPs) resulted in greater cytotoxicity against MCF-7 breast cancer cells. The antioxidant potential of Vallisneria spiralis L. was assessed using 2-diphenyl-1-picryl-hydroxyl (DPPH) radical scavenging assay, which showed promising results. In silico analysis involved molecular docking of Vallisneria spiralis L. phytocompounds with the target protein (PDB ID: 3CZH). This study presents a novel approach to breast cancer treatment by developing a nanoparticle-based drug delivery system derived from Vallisneria spiralis L.
Source: Bioinformation
Institution: Lincoln University College
Language: English
Topic: Medicinal Plant Research
Subfield: Plant Science
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4407102338