Work

A clear approach: Hemostatic gel as a novel adjunct for pediatric upper gastrointestinal bleeding

Year: 2025

Type: article

Abstract: Pediatric upper gastrointestinal bleeding (UGIB) is a significant clinical concern, with a mortality rate of approximately 2%. Endoscopic management of UGIB in children includes various techniques such as injections, mechanical devices, thermal therapies, and topical agents. PuraStat®, a clear hemostatic gel, has been used in adults to create a physical barrier for hemostasis without obscuring the endoscopic view. However, its use in pediatric UGIB has not been well-documented. A review of four pediatric cases where PuraStat® was used to treat UGIB showed that it was applied as an adjunct to other hemostatic methods like clip placement or epinephrine injections, and in one case, as monotherapy for a large duodenal ulcer/site of recently contained perforation. The gel was easy to use, appeared to be beneficial, and was well-tolerated in this small cohort, although conclusions regarding its safety and efficacy are limited by the sample size.

Source: JPGN Reports

DOI: 10.1002/jpr3.70000

Authors: Natalia Plott, Audra Rougraff, Paroma Bose, Kyla M. Tolliver, Shamaila Waseem, Brett J. Hoskins

Institutions: Indiana University Health, Riley Hospital for Children, Indiana University School of Medicine

Language: English

Topic: Gastrointestinal Bleeding Diagnosis and Treatment

Subfield: Gastroenterology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $1,900