Work

Toxic epidermal necrolysis induced by moxifloxacin and exacerbated by clindamycin in an elderly patient: A case report

Year: 2025

Type: article

Abstract: Toxic Epidermal Necrolysis (TEN) is a severe skin-mucosal reaction induced by medications, commonly characterized by blister formation and widespread epidermal detachment. Typical causative agents include allopurinol, antibiotics, anticonvulsants, and non-steroidal anti-inflammatory drugs (NSAIDs), with trimethoprim/sulfamethoxazole and penicillin being the most frequently implicated among antibiotics. However, lincosamide antibiotics as the cause of aggravation are rarely reported in clinical settings. This case report presents a patient with TEN induced by quinolone antibiotics, who experienced rapid progression of the condition after combining with lincomycin antibiotics. Clinical remission was achieved through a combination of corticosteroids, intravenous immunoglobulin, and plasma exchange therapy. This report aims to enhance clinicians' understanding of TEN by providing a detailed case presentation and discussion.

Source: Frontiers in Medicine

DOI: 10.3389/fmed.2025.1527051

Authors: Yongguang Wang, Qizheng Guo, Zhenyang Li, Guifen Gan, Chun Pan

Institutions: Qinghai University, Qinghai University Affiliated Hospital, University of Electronic Science and Technology of China, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital

Language: English

Topic: Drug-Induced Adverse Reactions

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801