De novo small cell neuroendocrine prostate cancer: An atypical case presentation
Year: 2025
Type: article
Study design: Case Report
Abstract: Small cell neuroendocrine carcinoma comprises less than 1 % of all prostate cancers. We report a case of a 62-year-old male who presented acutely with severe lower urinary tract symptoms (LUTS), including nocturia, but with normal prostate-specific antigen (PSA) levels. A tender, stony-hard prostate on digital rectal examination (DRE) led to prostate biopsy and imaging. The biopsy confirmed neuroendocrine carcinoma, and chemotherapy was initiated. This case emphasizes the atypical presentation of neuroendocrine prostate cancer with acute, severe LUTS and rapid progression, underscoring the potential for missed diagnoses when PSA levels are normal.
Source: Urology Case Reports
Authors: Yalda Rahmani, Yosra Abdul Hafez, Ammar Agha, M. Zaid Jarai, Nikos Mac Millan Basiliu, Elham Mahjoor Azad, Abdulmunem Alsadi, Kais Kotiesh, Mohammad Alhamad, Fariborz Bagheri
Institutions: Dubai Medical College, Dubai Hospital
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,160
OpenAlex ID: W4407121825