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Trendelenburg position is a reasonable alternative to passive leg raising for predicting volume responsiveness in mechanically ventilated patients in the ICU

Year: 2025

Type: article

Abstract: Passive leg raising (PLR) is a well-recognized method for assessing volume responsiveness in the intensive care unit (ICU); however, it has some limitations. The physiology of the cardiac preload induced by the Trendelenburg position and PLR is similar. The Trendelenburg position can be initiated from the supine position and then tilted downward (TREND SUPINE ) or from the reverse Trendelenburg position and then tilted further downward (TREND rTREND ). Therefore, this study aimed to compare the predictive performance of the percentage change in stroke volume index (ΔSVI) induced by TREND SUPINE , TREND rTREND , and PLR for volume responsiveness in mechanically ventilated patients in the ICU. The study was a prospective single-center cohort study conducted in a comprehensive ICU. The study consisted of the following sequential steps: (1) baseline-1: supine position with a 0° bed angulation; (2) Trendelenburg position: 15° downward bed angulation; (3) baseline-2: the same position as baseline-1; (4) reverse Trendelenburg position: 15° upward bed angulation; (5) Trendelenburg position: 15° downward bed angulation; (6) baseline-3: the same position as baseline-1; (7) semi-recumbent position: trunk elevated at 45°; (8) PLR: lower limbs elevated at 45° and trunk in the supine position; (9) baseline-4: the same position as baseline-1; (10) volume loading test: 250 ml of 4% albumin was infused over 10 min. At each time point, hemodynamic parameters were monitored using pulse contour analysis. A positive volume response was defined as an increase of at least 15% in SVI on pulse contour monitoring from baseline-4 after the volume loading test. The receiver operating characteristic curves were performed for ΔSVI. In this study, 36 patients were included for analysis, and of these, 15 patients (42%) were volume-responsive. TREND SUPINE -induced ΔSVI (ΔSVI SUPINE-TREND ), TREND rTREND -induced ΔSVI (ΔSVI rTREND-TREND ) and PLR-induced ΔSVI (ΔSVI PLR ) were 6%, 16%, and 11%, respectively (ΔSVI SUPINE-TREND vs. ΔSVI rSUPINE-TREND , p < 0.001; ΔSVI SUPINE-TREND vs. ΔSVI PLR , p < 0.05). The R 2 values of the linear regression between ΔSVI SUPINE-TREND , ΔSVI rTREND-TREND , ΔSVI PLR and volume loading test-induced ΔSVI were 0.14, 0.32, and 0.43, respectively (all p < 0.001). Furthermore, the area under the receiver operating characteristic curve for predicting volume responsiveness was 0.78 [95% confidence interval (CI), 0.59–0.92], 0.88 (95%CI, 0.75–0.96), and 0.83 (95%CI, 0.61–0.95) for TREND SUPINE , TREND rTREND , and PLR-induced ΔSVI, respectively, with no statistically significant difference among them. The sensitivity and specificity for predicting volume responsiveness were 93% and 67% for ΔSVI SUPINE-TREND at 4% cutoff, 87% and 76% for ΔSVI rTREND-TREND at 13% cutoff, and 73% and 86% for ΔSVI PLR at 11% cutoff. The Trendelenburg position (TREND SUPINE and TREND rTREND )-induced and PLR-induced percentage changes in SVI were similar in their ability to predict volume responsiveness in mechanically ventilated patients in the ICU. Considering that TREND rTREND induced greater percentage changes in SVI, it is preferentially recommended as a reasonable alternative to PLR for predicting volume responsiveness in certain clinical scenarios. Trial registration : ChiCTR2300067694. Registered on January 18, 2023.

Source: Critical Care

DOI: 10.1186/s13054-025-05301-1