Work

Three-component reactions of conjugated dienes, CH acids and formaldehyde under diffusion mixing conditions

Year: 2025

Type: article

Abstract: A diffusion mixing technique with a volatile reagent was successfully used to generate crotonic condensation adducts of active methylene compounds and formaldehyde at room temperature in the absence of strong acids and bases. The formed adducts were highly reactive intermediates capable of reacting with dienes in a three-component reaction, leading to the formation of Diels-Alder main reaction products.

Source: Beilstein Journal of Organic Chemistry

DOI: 10.3762/bjoc.21.18

Authors: Dmitry E Shybanov, Maxim E Kukushkin, Eugene V Babaev, Nikolai V Zyk, Elena K Beloglazkina

Institution: Lomonosov Moscow State University

Language: English

Topic: Organic Chemistry Cycloaddition Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funders: Russian Science Foundation, Lomonosov Moscow State University

Award: G1316824286