Year: 2025
Type: article
Abstract: High Resolution Image Download MS PowerPoint Slide Bis-cycloruthenated complexes (BCRCs) of the type [Ru(N^C) 2 L 2 ] are proposed to be key reactive intermediates in the Ru(II)-catalyzed directed C–H functionalization of arenes. While the exceptional ground state reactivity of BCRCs toward a number of electrophiles has been explored, their reactivity upon photoexcitation is still unknown. Herein, we report studies on the photoexcitation of BCRCs that establish their capability to access chemically useful excited states. Remarkably, photoexcited BCRCs demonstrate greatly increased reactivity toward the electron transfer processes required for alkyl halide activation, overcoming current limitations of their ground-state reactivity. We have demonstrated this reactivity by expanding upon the current chemical space occupied by Ru-catalyzed C–H functionalization to include ortho -alkylation with epoxides.
DOI: 10.1021/jacs.4c14835
Authors: Kurt Bentley, Mishra Deepak Hareram, Gang-Wei Wang, Alexander A. V. Millman, Ignacio Perez-Ortega, Luke M. Nichols, Cassandre C. Bories, Lauren E. Walker, Adam W. Woodward, Alexander P. Golovanov, Louise S. Natrajan, Igor Larrosa
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
OpenAlex ID: W4407144775