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A Rare Case of Severe Vitamin D Deficiency Presenting as Diffuse Osteosclerosis

Year: 2025

Type: article

Abstract: Maintaining calcium homeostasis is essential for various physiologic processes, with vitamin D playing a key role. Hyperparathyroidism typically causes fragility fractures and osteolytic lesions but rare cases can present with osteosclerosis. We report a 64-year-old woman with a history of gastric bypass presenting with back pain who was found to have diffuse osteosclerosis and hyperparathyroidism due to severe vitamin D deficiency. Nutritional supplementation led to symptom resolution. This case underscores the importance of considering bone-mineral pathology in patients with unexplained pain and highlights the need for close follow-up in postoperative care after bariatric surgery.

Source: Annals of Internal Medicine Clinical Cases

DOI: 10.7326/aimcc.2024.0647

Authors: Dayna J. Isaacs, Renae A. Tessem, Claire E. Drolen, Estebes A. Hernandez

Institution: University of California, Los Angeles

Language: English

Topic: Vitamin D Research Studies

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4407149404

FWCI:

Cites: 14

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Related to: 10