Work

Gentiopicroside alleviates neuroinflammation in Parkinson's disease by mediating microglial pyroptosis via the NF-κB/NLRP3/GSDMD pathway.

Year: 2025

Type: article

Abstract: OBJECTIVE: experiments, focusing on elucidating the underlying mechanisms of its action. METHODS: ). The expression of pro-inflammatory molecules was quantified using enzyme-linked immunosorbent assay (ELISA), while pyroptosis was analyzed by flow cytometry with caspase-1/PI double staining. The expression of key factors in the nuclear factor-kappa B (NF-κB)/NOD-like receptor thermal protein domain-associated protein 3 (NLRP3)/gasdermin D (GSDMD) signaling pathway was determined by immunoblotting. RESULTS: settings. CONCLUSION: GPS exhibits neuroprotective effects in PD by suppressing microglia-mediated neuroinflammation and pyroptosis, suggesting its potential as a favorable therapeutic agent for PD treatment.

Source: PubMed

DOI: 10.14670/hh-18-879

Authors: Hong Shen, Hui Song, Qiang Sun

Institutions: Suzhou Traditional Chinese Medicine Hospital, Hubei University of Medicine, Taihe Hospital

Language: English

Topic: Neuroinflammation and Neurodegeneration Mechanisms

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4407151682

FWCI: 0.597

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Cited by: 2

Related to: 10