Work

Management Considerations in a Patient With a Germline CDH1 Pathogenic Variant and a History of Roux-en-Y Gastric Bypass Surgery

Year: 2025

Type: article

Abstract: ABSTRACT Individuals with a germline pathogenic variant in the CDH1 gene have a lifetime risk of advanced diffuse gastric cancer (DGC) of up to 10.3% and a 37%–52% risk of breast cancer, specifically the lobular subtype. Guidelines recommend prophylactic gastrectomy between ages 18-40 years for those with a family history of DGC. For patients declining surgery or lacking a family history of DGC, annual endoscopic surveillance according to recommended protocols is an alternative. This case reviews the management of a patient with a history of Roux-en-Y gastric bypass followed one year later by a diagnosis of lobular breast cancer due to a germline CDH1 pathogenic variant.

Source: ACG Case Reports Journal

DOI: 10.14309/crj.0000000000001616

Authors: Zehra Naseem, Lady Katherine Mejia-Perez, Kenneth Friedman, Lisa LaGuardia, R. Matthew Walsh, Carol A. Burke

Institution: Cleveland Clinic

Language: English

Topic: Gastric Cancer Management and Outcomes

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4407152644

FWCI:

Cites: 20

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Related to: 10